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A potent MEK5 inhibitor
Catalog #: 2670
SKU-Size Size Price Qty
2670-1 1 mg
2670-5 5 mg
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Product Details

Alternate Name (Z)-3-(((3-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide
Appearance Crystalline solid
CAS # 1094614-85-3
Molecular Formula C₂₇H₂₈N₄O₂
Molecular Weight 440.54
Purity ≥98% by HPLC
Solubility DMSO (>50 mg/ml)
InChi InChI=1S/C27H28N4O2/c1-30(2)17-18-9-8-12-21(15-18)28-25(19-10-6-5-7-11-19)24-22-14-13-20(27(33)31(3)4)16-23(22)29-26(24)32/h5-16,28H,17H2,1-4H3,(H,29,32)/b25-24-
PubChem CID 46931012
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


BIX02189 is a potent MEK5 inhibitor (IC₅₀ = 1.5 nM). Also inhibits ERK5 catalytic activity (IC₅₀ = 59 nM). Does not inhibit closely related kinases MEK1, MEK2, ERK2 and JNK2.

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