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A curcumin analogue with anti-inflammatory and anti-proliferative properties
Catalog #: B2944
SKU-Size Size Price Qty
B2944-50 50 mg
B2944-250 250 mg
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Product Details

Alternate Name (1E,6E)-1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione; Didemethoxycurcumin; Curcumin III; Bis(4-hydroxycinnamoyl)methane; Bis(p-hydroxycinnamoyl)methane; Curcuminoid A; Curcumin Lll; DidemethoxycurcumiI; di-p-coumaroylmethane; 1,3-Di(4-hydroxystyryl)propanedial; 1,7-bis(4-hydroxyphenyl)-3-hydroxy-1,3,6-heptatrien-5-one; BDMC
Appearance A crystalline solid
CAS # 24939-16-0, 33171-05-0
Molecular Formula C₁₉H₁₆O₄
Molecular Weight 308.33
Purity >98.0%
Solubility ~5 mg/ml in ethanol, ~14 mg/ml in DMF, ~10 mg/ml in DMSO
InChi InChI=1S/C19H16O4/c20-16-7-1-14(2-8-16)5-11-18(22)13-19(23)12-6-15-3-9-17(21)10-4-15/h1-12,20-21H,13H2/b11-5+,12-6+
PubChem CID 5315472
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


Bisdemethoxycurcumin is a curcumin analogue with anti-inflammatory and anti-proliferative properties. It suppresses tumor necrosis factor (TNF)-induced nuclear factor-kappaB (NF-kappaB) activation in KBM-5 cells and inhibits proliferation of different cell lines at 25 μM. Bisdemethoxycurcumin enhances phagocytosis of amyloid-beta and transcription of MGAT3 and TLR. It down-regulates the transcriptional coactivator p300 and thereby inhibits the Wnt/beta-catenin pathway. It inhibits inducible nitric oxide synthase protein expression and accelerates healing of gastric ulcer in a rat model.

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