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Bisantrene dihydrochloride

An antineoplastic agent and a DNA intercalator
Catalog #: B2736
SKU-Size Size Price Qty
B2736-5 5 mg
$115.00
B2736-25 25 mg
$425.00
More Sizes Get Quote

Product Details

Alternate Name NSC 337766 N-[(E)-[10-[(E)-(4,5-dihydro-1H-imidazol-2-ylhydrazinylidene)methyl]anthracen-9-yl]methylideneamino]-4,5-dihydro-1H-imidazol-2-amine;dihydrochloride
Peptide Sequence N/A
Appearance Yellow to orange brown solid
CAS # 78186-34-2
Molecular Formula C₂₂H₂₄Cl₂N₈
Molecular Weight 471.39
Purity ≥98%
Solubility ~8 mg/ml Water
SMILES C1CN=C(N1)NN=CC2=C3C=CC=CC3=C(C4=CC=CC=C42)C=NNC5=NCCN5.Cl.ClIn
InChi InChI=1S/C22H22N8.2ClH/c1-2-6-16-15(5-1)19(13-27-29-21-23-9-10-24-21)17-7-3-4-8-18(17)20(16)14-28-30-22-25-11-12-26-22;;/h1-8,13-14H,9-12H2,(H2,23,24,29)(H2,25,26,30);2*1H/b27-13+,28-14+;;
InChi Key KINULKKPVJYRON-PVNXHVEDSA-N
PubChem CID 6917792
MDL Number MFCD01743164
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Bisantrene dihydrochloride is the hydrochloride salt of an anthracenyl bishydrazone with antineoplastic activity. It intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin (Cat. No. 1527) in activity, but unlike doxorubicin, does not exhibit cardiotoxicity. Bisantrene can be used to select for P-glycoprotein-mediated multiple drug resistance


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