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Bioymifi

A potent and selective death receptor 5 (DR5) activator
Catalog #: 9424
SKU-Size Size Price Qty
9424-5 5 mg
$115.00
9424-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name (Z)-5-(5-[(3-[4-Bromophenyl]-2-imino-4-oxothiazolidin-5-ylidene)methyl]furan-2-yl)isoindoline-1,3-dione
Appearance Orange to dark orange solid
CAS # 1420071-30-2
Molecular Formula C₂₂H₁₂BrN₃O₄S
Molecular Weight 494.32
Purity ≥98% by HPLC
Solubility DMSO (~ 2 mg/ml)
SMILES C1=CC(=CC=C1N2C(=O)C(=CC3=CC=C(O3)C4=CC5=C(C=C4)C(=O)NC5=O)SC2=N)Br
InChi InChI=1S/C22H12BrN3O4S/c23-12-2-4-13(5-3-12)26-21(29)18(31-22(26)24)10-14-6-8-17(30-14)11-1-7-15-16(9-11)20(28)25-19(15)27/h1-10,24H,(H,25,27,28)/b18-10-,24-22?
InChi Key ULBOWKXOFOTCMU-NLDKGBHCSA-N
PubChem CID 70678419
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Bioymifi is a potent and selective death receptor 5 (DR5) activator. Bioymifi works by mimicking the ability of TRAIL, the natural DR5 ligand, to stimulate clustering of DR5, triggering apoptosis. Bioymifi caused apoptosis and cell death in a variety of human cancer cell lines including T98G human glioblastoma cells, lung cancer cell lines H460 and H1155, the cervical cancer cell line HeLa, the osteosarcoma cell line U2OS, the pancreatic carcinoma cell line Miapaca and the colon cancer cell line HT29.


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