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Biotinylated PD-1/PDCD1, Human Recombinant

Inhibits the T-cell proliferation and production of IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway.
Catalog #: P1038
SKU-Size Size Price Qty
P1038-10 10 μg
$175.00
P1038-50 50 μg
$575.00
More Sizes Get Quote

Product Details

Alternate Name PDCD1, PD1, CD279, SLEB2, hPD-1, hPD-l
Gene Symbol PDCD1
Gene ID 5133
Accession # Q15116
Source E. coli
Appearance Liquid
Physical Form Description 0.5 mg/ml solution in in PBS containing 20% glycerol
Molecular Weight 19.7 kDa
Purity by SDS-PAGE > 90%
Purity by > 90%
Biological Activity Measured by its binding ability to bind Human PD-L1 in a functional ELISA with a linear range of 0.125-1 µg/ml.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Programmed death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer. This protein is suitable for use in protein studies such as protein structure analysis and protein-protein interactions. It can also be used as an immunogen, as a protein standard, or in cell biology research applications.


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