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Biotin-IETD-FMK

A Caspase-8 inhibitor
Catalog #: 1121
$295.00

Product Details

Cat # +Size 1121-20C
Size 20 µl (10 mM)
Alternate Name Biotin-IETD-FMK, IETD-FMK, Biotin-
Peptide Sequence Biotin-Ile-Glue(OMe)-Thr-Asp(OMe)-FMK
Appearance Liquid
Formulation DMSO (10 mM)
Molecular Formula C₃₈H₆₂FN₇O₁₂S
Molecular Weight 860
Purity >95% by HPLC
SMILES CCC(C)C(C(=O)NC(CCC(=O)OC)C(=O)NC(C(C)O)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)CCCCCNC(=O)CCCCC1C2C(CS1)NC(=O)N2
InChi InChI=1S/C38H62FN7O12S/c1-6-21(2)32(44-29(50)14-8-7-11-17-40-28(49)13-10-9-12-27-34-25(20-59-27)43-38(56)46-34)36(54)41-23(15-16-30(51)57-4)35(53)45-33(22(3)47)37(55)42-24(26(48)19-39)18-31(52)58-5/h21-25,27,32-34,47H,6-20H2,1-5H3,(H,40,49)(H,41,54)(H,42,55)(H,44,50)(H,45,53)(H2,43,46,56)
InChi Key IYEFTEIWZOFJHC-UHFFFAOYSA-N
PubChem CID 44135228
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A synthetic peptide that irreversibly inhibits activity of caspase-8 and related caspases and blocks apoptosis. The inhibitor is designed as a methyl ester to enhance cell permeability. The conjugation with biotin allows detection of activated caspases in conjunction with avidin-tags. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).


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