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BioSim™ anti-Avelumab (Bavencio®) (Human) ELISA Kit

A Sandwich ELISA kit for the qualitative determination of antibody against Avelumab in human serum or plasma.
Catalog #: E4557

In stock

$1,050.00

Product Details

Cat # +Size E4557-100
Size 100 assays
Detection Method Absorbance (450 nm)
Species Reactivity Human
Applications Qualitative determination of antibody against Avelumab (Bavencio) in serum and plasma
Features & Benefits Easy, convenient, sensitive and time-saving method toqualitative determination of antibody against Avelumab (Bavencio) in human serum and plasma. Cross Reactivity: Avelumab (Bavencio®) infusion camouflages/masks the presence of antibody to Avelumab in serum/plasma samples. Therefore, blood sampling time is critical for detection of antibody to Avelumab. It is convenient to obtain blood sample just before the infusion or at least 2 weeks after the infusion of Pembrolizumab.
Kit Components • Micro ELISA Plate • Positive Control • Negative Control • Assay Buffer • Peroxidase Conjugate • TMB substrate (Avoid light) • Stop Solution • Wash buffer (20X) • Plate sealers
Storage Conditions 4°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Avelumab (Bavencio®) is a fully human anti-PD-L1 IgG1 lambda monoclonal antibody that has a molecular weight of approximately 147 kDa. Avelumab binds PD-L1 and blocks the interaction between PD-L1 and its receptors PD-1 and B7-1. By inhibiting PD-L1 interactions, avelumab is thought to enable the activation of T-cells and the adaptive immune system. By retaining anative Fc-region, avelumab is thought to engage the innate immune system and may induce antibody-dependent cell-mediated cytotoxicity. Importantly, avelumab has not shown antibody-dependent cell mediated cytotoxicity against immune cell subsets in humans. However, some patients develop unwanted immunogenicity, which leads to production of anti-drug-antibodies (ADAs) inactivating the therapeutic effects of the treatment and, in rare cases, inducing adverse effects. BioVision’s BioSim™ anti-Avelumab ELISA kit is designed to detect antibody against Avelumab with high specificity and sensitivity in biological matrices.


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