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Product Details
| Cat # +Size | 1673-1 |
|---|---|
| Size | 1 mg |
| Alternate Name | (2Z, 3E)-6’-Bromo-3-(hydroxyimino)-[2,3’-biindolinylidene]-2’-one |
| Appearance | Crystalline solid |
| CAS # | 667463-62-9 |
| Molecular Formula | C₁₆H₁₀BrN₃O₂ |
| Molecular Weight | 356.17 |
| Purity | ≥98% |
| Solubility | DMSO (10 mg/ml) or EtOH (0.5 mg/ml) |
| SMILES | C1=CC2=C(C(=C3C4=C(C=C(C=C4)Br)NC3=O)N=C2C=C1)NO |
| InChi | InChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,20,22H,(H,19,21)/b15-13- |
| InChi Key | WNWSUJQVZJJGLF-SQFISAMPSA-N |
| PubChem CID | 5287844 |
| MDL Number | MFCD08705318 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/β (IC₅₀ = 5 nM). Under a feeder-free condition, BIO maintains embryonic stem cells (hESCs) in the undifferentiated state.
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Zhou et al., Phosphorylation of the cytoskeletal protein CAP1 controls its association with cofilin and actin. J. Cell Sci., Dec 2014; 127: 5052 - 5065.
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