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BIO

based on 1 citations in multiple journalsBIO14.1 4
A GSK-3 inhibitor
Catalog #: 1673

In stock

$100.00

Product Details

Cat # +Size 1673-1
Size 1 mg
Alternate Name (2Z, 3E)-6’-Bromo-3-(hydroxyimino)-[2,3’-biindolinylidene]-2’-one
Appearance Crystalline solid
CAS # 667463-62-9
Molecular Formula C₁₆H₁₀BrN₃O₂
Molecular Weight 356.17
Purity ≥98%
Solubility DMSO (10 mg/ml) or EtOH (0.5 mg/ml)
SMILES C1=CC2=C(C(=C3C4=C(C=C(C=C4)Br)NC3=O)N=C2C=C1)NO
InChi InChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,20,22H,(H,19,21)/b15-13-
InChi Key WNWSUJQVZJJGLF-SQFISAMPSA-N
PubChem CID 5287844
MDL Number MFCD08705318
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/β (IC₅₀ = 5 nM). Under a feeder-free condition, BIO maintains embryonic stem cells (hESCs) in the undifferentiated state.


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Zhou et al., Phosphorylation of the cytoskeletal protein CAP1 controls its association with cofilin and actin. J. Cell Sci., Dec 2014; 127: 5052 - 5065.
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