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BID, Human Recombinant

Pro-apoptotic Bcl-2 protein
Catalog #: P1571
SKU-Size Size Price Qty
P1571-10 10 μg
$105.00
P1571-50 50 μg
$495.00
More Sizes Get Quote

Product Details

Alternate Name BH3-interacting domain death agonist, p22 BID, p11 BID
Gene Symbol BID
Gene ID 637
Accession # P55957
Source E. coli
Appearance Sterile Filtered colorless solution
Physical Form Description In 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol
Molecular Weight 21.9 kDa
Purity by SDS-PAGE >95%
Amino Acid Sequence aa 1-195
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BID is a pro-apoptotic Bcl-2 protein containing only the BH3 domain. In response to apoptotic signaling, BID interacts with another Bcl-2 family protein, Bax, leading to the insertion of Bax into the outer mitochondrial membrane. Bax is believed to induce the opening of the mitochondrial voltage-dependent anion channel. This results in the release of cytochrome c and other pro-apoptotic factors from the mitochondria leading to activation of caspases. Recombinant BID protein was expressed in E. coli and purified by using conventional chromatography techniques.


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