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Bid Antibody

based on 6 citations in multiple journalsBid Antibody64.1 4
Catalog #: 3172
SKU-Size Size Price Qty
3172-30T 30 µg
$89.00
3172-100 100 µg
$245.00
More Sizes Get Quote

Product Details

Antibody Target Bid
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide surrounding amino acid 37 of human Bid
Accession # P55957
Gene ID 637
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit anti-Bid polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Purification Affinity purified
Species Reactivity Human
Application Western blot, Immunoprecipitation, Immunohistochemistry
Application & Usage Western blot analysis (0.5-4 µg/ml), immunoprecipitation (5-10 µg/ml), and Immunohistochemistry (20-40 µg/ml). However, the optimal conditions should be determined individually. The antibody detects 22 kDa human Bid
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Bid, a BH3 domain-containing proapoptotic Bcl-2 family member, is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by caspase-8 in the Fas signaling pathway. Cleaved Bid translocates to mitochondria and releases its potent proapoptotic activity, which in turn induces cytochrome c release and mitochondrial damage. The cytochrome c releasing activity of Bid was antagonized by Bcl-2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In the animal model studies, Bid-deficient mice are found resistant to the lethal effects of death factor signals relayed throμgh Fas.


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Chen M et al. (2007) Blood 109: 4360-4367.
Huang X. et al. (2007) J. Biol. Chem. 282: 29401-29413.
Ju W et al. (2007) PNAS 104: 14294 -14299.
Huang C-J et al. (2007)Am. J. Physiol. Endocrinol Metab. 10.1152/aipendo.00318.2007.
Kulik, G., et al. (2001) Cancer Res. 61:2713-2719.
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