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BIBX-1382

An EGFR tyrosine kinase inhibitor
Catalog #: 9463
SKU-Size Size Price Qty
9463-5 5 mg
$125.00
9463-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name N8-(3-chloro-4-fluorophenyl)-N2-(1-methylpiperidin-4-yl)pyrimido[5,4-d]pyrimidine-2,8-diamine
Appearance Light yellow solid
CAS # 196612-93-8
Molecular Formula C₁₈H₁₉ClFN₇
Molecular Weight 387.84
Purity ≥98% by HPLC
Solubility DMSO (>20 mg/ml)
SMILES N1CCC(CC1)NC2=NC=C3C(=N2)C(=NC=N3)NC4=CC(=C(C=C4)F)Cl
InChi InChI=1S/C18H19ClFN7/c1-27-6-4-11(5-7-27)25-18-21-9-15-16(26-18)17(23-10-22-15)24-12-2-3-14(20)13(19)8-12/h2-3,8-11H,4-7H2,1H3,(H,21,25,26)(H,22,23,24)
InChi Key FTFRZXFNZVCRSK-UHFFFAOYSA-N
PubChem CID 6918508
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BIBX 1382 is a potent, selective, reversible and ATP-competitive inhibitor of EGFR tyrosine kinase (IC₅₀ = 3 nM); displays > 1000-fold lower potency against ErbB2 (IC₅₀ = 3.4 μM) and a range of other related tyrosine kinases (IC₅₀ > 10 μM).


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