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BIBF1120

A triple angiokinase inhibitor
Catalog #: 2167
SKU-Size Size Price Qty
2167-5 5 mg
$75.00
2167-25 25 mg
$310.00
More Sizes Get Quote

Product Details

Alternate Name (Z)-​methyl 3-​(((4-​(N-​methyl-​2-​(4-​methylpiperazin-​1-​ yl)acetamido)phenyl)amino)(phenyl)methylene)-​2-​oxoindoline-​6-​ carboxylate; Nintedanib; Vargatef; Ofev
Appearance White to off-white solid
CAS # 656247-17-5
Molecular Formula C₃₁H₃₃N₅O₄
Molecular Weight 539.62
Purity ≥95%
Solubility DMSO (~ 6 mg/ml) or EtOH (~ 3 mg/ml)
SMILES CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)NC(=C3C4=C(C=C(C=C4)C(=O)OC)NC3=O)C5=CC=CC=C5
InChi InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21) 28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-
InChi Key XZXHXSATPCNXJR-ZIADKAODSA-N
PubChem CID 9809715
MDL Number MFCD11974012
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BIBF1120 is a triple angiokinase inhibitor. It blocks signaling through vascular endothelial growth factor receptors (VEGFR; IC₅₀ values of 13 to 34 nM), platelet-derived growth factor receptors (PDGFR; IC₅₀ values of 59 to 65 nM), and fibroblast growth factor receptors (FGFR; IC₅₀ values of 37 to 610 nM).


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