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BI-D1870

An ATP-competitive inhibitor of the four isoforms of ribosomal S6 kinase (p90 RSK)
Catalog #: 1924
SKU-Size Size Price Qty
1924-1 1 mg
$85.00
1924-5 5 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name 2-[(3,5-Difluoro-4-hydroxyphenyl)amino]-7,8-dihydro-5,7-dimethyl-8-(3-methylbutyl)-6(5H)-pteridone
Appearance Pale orange solid
CAS # 501437-28-1
Molecular Formula C₁₉H₂₃F₂N₅O₂
Molecular Weight 391.42
Purity ≥98% by TLC
Solubility DMSO (>25 mg/ml)
SMILES CC1C(=O)N(C2=CN=C(N=C2N1CCC(C)C)NC3=CC(=C(C(=C3)F)O)F)C
InChi InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24)
InChi Key DTEKTGDVSARYDS-UHFFFAOYSA-N
PubChem CID 25023738
MDL Number MFCD11223662
Handling Protect from light and air
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. ATP-competitive inhibitor of the four isoforms of ribosomal S6 kinase (p90 RSK) (IC₅₀'s at 100 µM ATP: RSK1 = 31 nM, RSK2 = 24 nM, RSK3 = 18 nM, RSK4 = 15 nM). Does not significantly inhibit 10 other AGC kinases, and over 40 other protein kinases at 100X concentrations. In addition, BI-D1870 completely prevents PMA-induced TSC2 (a regulator of mTORC1) phosphorylation at Ser¹⁷⁹⁸.


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