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BI-847325

an ATP-competitive dual inhibitor of MEK and Aurora kinases.
Catalog #: B1589

In stock

SKU-Size Size Price Qty
B1589-5 5 mg
$175.00
B1589-25 25 mg
$695.00

Product Details

Alternate Name (Z)-3-(3-((4-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide
Appearance Crystalline solid
CAS # 1207293-36-4 
Molecular Formula C₂₉H₂₈N₄O₂ 
Molecular Weight 464.57
Purity ≥98% by HPLC
Solubility DMSO
SMILES CCNC(=O)C#CC1=CC2=C(C=C1)C(=C(C3=CC=CC=C3)NC4=CC=C(C=C4)CN(C)C)C(=O)N2
InChi InChI=1S/C29H28N4O2/c1-4-30-26(34)17-13-20-12-16-24-25(18-20)32-29(35)27(24)28(22-8-6-5-7-9-22)31-23-14-10-21(11-15-23)19-33(2)3/h5-12,14-16,18,31H,4,19H2,1-3H3,(H,30,34)(H,32,35)/b28-27-
InChi Key FLBNLJLONKAPLR-DQSJHHFOSA-N
PubChem CID 54577344
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BI-847325 is an ATP-competitive dual inhibitor of MEK and Aurora kinases. Potent inhibition of MEK1/2 and Aurora A/B kinases by BI-847325 was demonstrated in enzymatic and cellular assays. 


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