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BI 6727

A polo-like kinase (PLK) inhibitor
Catalog #: 2222
SKU-Size Size Price Qty
2222-1 1 mg
$65.00
2222-5 5 mg
$255.00
More Sizes Get Quote

Product Details

Alternate Name Volasertib
Appearance White to off-white solid
CAS # 755038-65-4
Molecular Formula C₃₄H₅₀N₈O₃
Molecular Weight 618.81
Purity ≥98% by HPLC
Solubility DMSO
SMILES CCC1C(=O)N(C2=CN=C(N=C2N1C(C)C)NC3=C(C=C(C=C3)C(=O)NC4CCC(CC4)N5CCN(CC5)CC6CC6)OC)C
InChi InChI=1S/C34H50N8O3/c1-6-28-33(44)39(4)29-20-35-34(38-31(29)42(28)22(2)3)37-27-14-9-24(19-30(27)45-5)32(43)36-25-10-12-26(13-11-25)41-17-15-40(16-18-41)21-23-7-8-23/h9,14,19-20,22-23,25-26,28H,6-8,10-13,15-18,21H2,1-5H3,(H,36,43)(H,35,37,38)/t25?,26?,28-/m1/s1
InChi Key SXNJFOWDRLKDSF-XKHVUIRMSA-N
PubChem CID 10461508
MDL Number MFCD20926414
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A highly potent, selective and ATP-competitive inhibitor of polo-like kinases 1, 2 and 3 (PLK1, 2 and 3), with IC₅₀s at 0.87, 5 and 56 nM, respectively.


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