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A potent and selective PDE9A inhibitor
Catalog #: B2377
SKU-Size Size Price Qty
B2377-5 5 mg
B2377-25 25 mg
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Product Details

Alternate Name 6-(pyridin-2-ylmethyl)-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, BI409306, SUB 166499
Appearance Crystalline solid
CAS # 1189767-28-9
Molecular Formula C₁₆H₁₇N₅O₂
Molecular Weight 311.35
Purity ≥98% by HPLC
Solubility >50 mg/ml in DMSO
InChi InChI=1S/C16H17N5O2/c22-16-13-10-18-21(12-4-7-23-8-5-12)15(13)19-14(20-16)9-11-3-1-2-6-17-11/h1-3,6,10,12,18H,4-5,7-9H2
PubChem CID 44252845
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


BI-409306 is a potent and selective PDE9A inhibitor (IC50 = 52 nM). Displays weak activity against other PDEs, such as PDE1A (IC50, 1.4 µM), PDE1C (IC50, 1.0 µM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 > 10 µM). Potentially could be useful for the treatment of Alzheimer’s disease and Schizophrenia.

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