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BI-2536

based on 1 citations in multiple journalsBI-253614.1 4
A selective polo-like kinase 1 (PLK1) inhibitor
Catalog #: 2370
SKU-Size Size Price Qty
2370-5 5 mg
$115.00
2370-25 25 mg
$435.00
More Sizes Get Quote

Product Details

Alternate Name (R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
Appearance Crystalline solid
CAS # 755038-02-9
Molecular Formula C₂₈H₃₉N₇O₃
Molecular Weight 521.65
Purity ≥98% by HPLC
Solubility DMSO (~20 mg/ml) or Ethanol (~ 100 mg/ml)
SMILES CCC1C(=O)N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C(=O)NC5CCN(CC5)C)OC)C
InChi InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1
InChi Key XQVVPGYIWAGRNI-JOCHJYFZSA-N
PubChem CID 11364421
MDL Number MFCD10565924
Handling Protect from light and moisture
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BI-2536 is a potent, selective inhibitor of polo-like kinase 1 (PLK1) (IC₅₀ = 0.83 nM). It blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC₅₀ of 3.5 nM and 9.0 nM, respectively. BI-2536 potently causes a mitotic arrest and induces apoptosis in human cancer cell lines of diverse tissue origin.


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Luo & Kim. PLK4 Is Essential for Meiotic Resumption in Mouse Oocytes. Biol Reprod, Apr 2015; 92: 101.
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