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BH3I-1

A Bcl-2 family inhibitor
Catalog #: B1277

In stock

SKU-Size Size Price Qty
B1277-5 5 mg
$145.00
B1277-25 25 mg
$575.00
More Sizes Get Quote

Product Details

Alternate Name 5-[(4-bromophenyl)methylene]-a-(1-methylethyl)-4-oxo-2-thioxo-3-thiazolidineacetic acid
Appearance Yellow solid
CAS # 300817-68-9 
Molecular Formula  C₁₅H₁₄BrNO₃S₂ 
Molecular Weight 400.31
Purity ≥97% by HPLC
Solubility DMSO (>10 mg/ml)
SMILES CC(C)C(C(=O)O)N1C(=O)C(=CC2=CC=C(C=C2)Br)SC1=S
InChi InChI=1S/C15H14BrNO3S2/c1-8(2)12(14(19)20)17-13(18)11(22-15(17)21)7-9-3-5-10(16)6-4-9/h3-8,12H,1-2H3,(H,19,20)/b11-7+
InChi Key COHIEJLWRGREHV-YRNVUSSQSA-N
PubChem CID 6090108
MDL Number MFCD03453544
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BH3I-1 is a cell-permeable inhibitor that blocks the binding of BH3 peptides to Bcl-xL, inducing apoptosis. It inhibits interactions of BH3 domain-containing proteins with Bcl-xL, Bcl-2, and Bcl-W, inducing apoptosis in Bcl-2 or Bcl-W expressing cells with Ki values of 43.4 and 124 µM, respectively. BH3I-1 enhances radiation sensitivity in non-small cell lung cancer cells.


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