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BG-45

A potent HDAC class I inhibitor
Catalog #: B1866

In stock

SKU-Size Size Price Qty
B1866-5 5 mg
$95.00
B1866-25 25 mg
$375.00

Product Details

Alternate Name N-(2-Aminophenyl)pyrazine-2-carboxamide
Appearance White to of-white solid
CAS # 926259-99-6 
Molecular Formula C₁₁H₁₀N₄O
Molecular Weight 214.23
Purity ≥98% by HPLC
Solubility DMSO (>20 mg/ml)
SMILES C1=CC=C(C(=C1)N)NC(=O)C2=NC=CN=C2
InChi InChI=1S/C11H10N4O/c12-8-3-1-2-4-9(8)15-11(16)10-7-13-5-6-14-10/h1-7H,12H2,(H,15,16)
InChi Key LMWPVSNHKACEKW-UHFFFAOYSA-N
PubChem CID 16773791
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BG-45 is a potent HDAC class I inhibitor with selectivity for HDAC3 (IC₅₀ = 289 nM) over HDAC1, 2. BG45 does not inhibit HDAC6. BG-45 alone or in combination with bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma.


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