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BEZ235 (NVP-BEZ235)

based on 1 citations in multiple journalsBEZ235 (NVP-BEZ235)14.1 4
A PI3 Kinase inhibitor
Catalog #: 1626
SKU-Size Size Price Qty
1626-5 5 mg
$140.00
1626-25 25 mg
$320.00
More Sizes Get Quote

Product Details

Alternate Name NVP-BEZ235
Appearance Off-white to pale yellow solid
CAS # 915019-65-7
Molecular Formula C₃₀H₂₃N₅O
Molecular Weight 469.55
Purity ≥99% by HPLC
Solubility DMSO (10 mM)
SMILES CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5
InChi InChI=1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3
InChi Key JOGKUKXHTYWRGZ-UHFFFAOYSA-N
PubChem CID 11977753
MDL Number MFCD10565944
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

Orally active PI-3 kinase inhibitor; Dual PI3K/mTOR inhibition; BEZ235 showed high target specificity and demonstrated anti-proliferative activity against tumor cell lines in animal models of cancer.


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Yevgeny Berdichevsky et al., PI3K-Akt Signaling Activates mTOR-Mediated Epileptogenesis in Organotypic Hippocampal Culture Model of Post-Traumatic Epilepsy. J. Neurosci., May 2013; 33: 9056 - 9067.
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