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Betacellulin, Murine Recombinant

A potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells
Catalog #: 7119

In stock

SKU-Size Size Price Qty
7119-10 10 μg
$135.00
7119-50 50 μg
$575.00
More Sizes Get Quote

Product Details

Alternate Name BTC
Gene Symbol BTC
Gene ID 12223
Accession # Q05928
Source E. coli.
Appearance Lyophilized powder
Physical Form Description Sterile filtered through a 0.2 micron filter. Lyophilized with no additives.
Molecular Weight 9 kDa
Purity by SDS-PAGE ≥98%
Endotoxin Level < 0.1 ng/μg of protein (<1EU/μg).
Biological Activity Determined by its ability to stimulate the proliferation of mouse Balb/3T3 cells. The expected ED50 is ≤ 0.01 ng/ml, corresponding to a specific activity of ≥ 1 x 108 units/mg.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliq
Amino Acid Sequence DGNTTRTPET NGSLCGAPGE NCTGTTPRQK VKTHFSRCPK QYKHYCIHGR CRFVVDEQTP SCICEKGYFG ARCERVDLFY
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant murine Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein precursor.


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