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Benazepril hydrochloride

A potent angiotensin converting-Enzyme (ACE) inhibitor
Catalog #: B2138

In stock

SKU-Size Size Price Qty
B2138-50 50 mg
$75.00
B2138-250 250 mg
$225.00
More Sizes Get Quote

Product Details

Alternate Name (3S)-3-[(1S)-1-Ethoxycarbonyl-3-phenylpropyl]amino-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic Acid Hydrochloride; CGS 14824A
Appearance White solid
CAS # 86541-74-4
Molecular Formula C₂₄H₂₈N₂O₅·HCl
Molecular Weight 460.96
Purity ≥98% by HPLC
Solubility DMSO (>40 mg/ml) or H₂O (20 mg/ml)
SMILES CCOC(=O)C(CCC1=CC=CC=C1)NC2CCC3=CC=CC=C3N(C2=O)CC(=O)O.Cl
InChi InChI=1S/C24H28N2O5.ClH/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);1H/t19-,20-;/m0./s1
InChi Key VPSRQEHTHIMDQM-FKLPMGAJSA-N
PubChem CID 5362123
MDL Number MFCD00895734
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Benazepril is a prodrug of the angiotensin converting enzyme (ACE) inhibitor benazeprilat. It is metabolized to benazeprilat by hepatic esterases. Benazepril inhibits the in vitro enzymatic activity of partially purified ACE isolated from rabbit lung (IC₅₀ = 2 nM). Reduces blood pressure and myocardial hypertrophy in spontaneous hypertensive rats.


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