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Beclin 1 Antibody

based on 1 citations in multiple journalsBeclin 1 Antibody14.1 4
Catalog #: 3663
SKU-Size Size Price Qty
3663-30T 30 µg
$89.00
3663-100 100 µg
$245.00
More Sizes Get Quote

Product Details

Antibody Target Beclin 1
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide corresponding to residues around amino acid 25 of mouse Beclin 1
Accession # O88597
Gene ID 56208
Appearance Colorless liquid
Concentration 0.2 mg/ml
Formulation 100 µg (0.2mg/ml) protein A purified rabbit anti-Beclin 1 polyclonal antibody in phosphate-buffered saline (PBS) containing 1% BSA, 50% glycerol, and 0.02% thimerosal.
Purification Affinity purified
Species Reactivity Human, mouse
Application Western blot
Application & Usage Western blotting (0.5-2 µg/ml). However, the optimal concentrations should be determined individually. Other applications have not been tested. The antibody recognizes ~53 kDa beclin 1 in Jurkat cell lysate. A weak band of ~110 kDa (possibly dimer) can al
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Beclin is a Bcl-2 binding protein. Its structure includes a Bcl-2 binding coiled-coil region, and a leucine-rich nuclear export signal (NES). Beclin protein colocalizes with intracytoplasmic organelles and nuclei in normal COS7 and MCF7 cells. Beclin interaction with Bcl-2 may be involved with host viral defense, since over expression of beclin inhibits Sindbis virus replication and expression of beclin lacking the Bcl-2 binding domain has no antiviral effects.


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Mao L et al (2009) Lab Med; 40: 39 - 46.
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