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BDA366

A small-molecule Bcl2-BH4 domain antagonist
Catalog #: B1827
SKU-Size Size Price Qty
B1827-5 5 mg
$135.00
B1827-25 25 mg
$540.00
More Sizes Get Quote

Product Details

Alternate Name 1-[[3-(Diethylamino)-2(S)-hydroxypropyl]amino]-4-[(2(S)-oxiranylmethyl)amino]-9,10-anthracenedione
Appearance Crystalline solid
CAS # 1909226-00-1
Molecular Formula C24H29N3O4
Molecular Weight 423.5
Purity ≥98% by HPLC
Solubility DMSO (>40 mg/ml)
SMILES CCN(CC)C[[email protected]@H](O)CNC1=CC=C(NC[[email protected]@H]2OC2)C3=C1C(C4=C(C3=O)C=CC=C4)=O
InChi InChI=1S/C24H29N3O4/c1-3-27(4-2)13-15(28)11-25-19-9-10-20(26-12-16-14-31-16)22-21(19)23(29)17-7-5-6-8-18(17)24(22)30/h5-10,15-16,25-26,28H,3-4,11-14H2,1-2H3/t15-,16-/m0/s1
InChi Key JYOOEVFJWLBLKF-HOTGVXAUSA-N
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BDA-366 is a small-molecule Bcl2-BH4 domain antagonist, that binds BH4 with high affinity and selectivity. BDA-366-Bcl2 binding induces conformational change in Bcl2 that abrogates its antiapoptotic function, converting it from a survival molecule to a cell death inducer.


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