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BCRP (ABCG2) Antibody

Polyclonal antibody to detect BCRP in human samples
Catalog #: 6971
$325.00

Product Details

Cat # +Size 6971-100
Size 100 µg
Antibody Target BCRP (ABCG2)
Alternate Name Breast Cancer Resistance Protein, BCRP1, ATP-binding cassette sub-family G member 2, ATP binding cassette sub family G (WHITE) member 2, ABCG2, Mitoxantrone resistance associated protein, MXR, MXR1
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit Ig
Immunogen Synthetic peptide corresponding to amino acids around position 160 of human ABCG2
Accession # Q9UNQ0
Gene ID 9429
Appearance Solid
Formulation Each vial contains 5mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3, 0.05 mg Thimerosal
Purification Immunogen affinity purified antibody
Species Reactivity Human
Application Western Blot
Positive Control WB: HeLa cells, SW620 cells, MCF-7 cells, SKOV cells, Jurkat cell
Application & Usage WB: 1:1000-1:5000 of 0.5 mg/ml stock
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BCRP, also called ABCG2, is encoded by the ABCG2 gene. BCRP is a well-characterized ABC-transporter (which limits uptake or mediates efflux of a wide variety of drugs, carcinogens, dietary toxins across cellular membranes). It is an ATP-dependent pump with broad substrate specificity. Significant expression has been observed in the placenta and it has been shown to have a role in protecting the fetus from xenobiotics in the maternal circulation. It plays protective roles in blocking absorption at the apical membrane of the intestine, and at the blood-testis barrier, the blood–brain barrier and the membranes of hematopoietic progenitor and other stem cells. At the apical membranes of the liver and kidney, it enhances excretion of xenobiotics. In the lactating mammary gland, it has a role on excreting vitamins such as riboflavin and biotin into milk.


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