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BCl-2 Inhibitor, ABT-199

A potent BCl-2 inhibitor
Catalog #: 2253
SKU-Size Size Price Qty
2253-1 1 mg
$90.00
2253-5 5 mg
$240.00
More Sizes Get Quote

Product Details

Alternate Name 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4’-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1’-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide; GDC-0199; Venetoclax
Appearance White to off-white solid
CAS # 1257044-40-8
Molecular Formula C₄₅H₅₀ClN₇O₇S
Molecular Weight 868.44
Purity ≥98% by HPLC
Solubility DMSO (50 mM)
PubChem CID
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A potent and selective BCl-2 inhibitor that spares platelets while achieving potent antitumor activity.


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Charlène Niogret, Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells. Nat Commun, March 2019;  30926899.
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