Product Details
| Cat # +Size | 3195-100 |
|---|---|
| Size | 100 µg |
| Antibody Target | Bcl-2 |
| Alternate Name | BCL2, BCL 2 |
| Host | Mouse |
| Antibody Type | Monoclonal |
| Isotype | Mouse IgG1 |
| Immunogen | Synthetic peptide corresponding to resides surrounding a.a. 44 of Human Bcl-2 |
| Accession # | M13994 |
| Gene ID | 596 |
| Appearance | Colorless liquid |
| Concentration | 0.5 mg/ml |
| Formulation | 100 µg (0.5 mg/ml) protein A purified from (low FBS containing) tissue culture supernatant. Purity was >95%. The antibody was formulated in PBS containing 1 mg/ml BSA and 1.5 mM sodium azide and 50% glycerol |
| Purification | Affinity purified |
| Species Reactivity | Human |
| Application | Western blot, Immunoprecipitation, Immunohistochemistry |
| Application & Usage | Western blot (1-4 µg/ml), Immunoprecipitation, Immunohistochemistry, and Flow cytometry. However the optimal conditions should be determined individually. Recognize the 26 kDa human Bcl-2 |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Bcl-2 (B-cell leukemia/lymphoma 2) gene was discovered by walking the chromosomal breakpoints t(14;18). This gene consists of two exons and several transcripts that encode two different protein products, Bcl-2α and Bcl-2β. Both proteins are approximately 26-30 kDa and differ at their C-terminal region. Bcl-2 suppresses apoptosis (programmed cell death) and this property appears to be modulated by homodimerization or association with Bax and Bad, two cell death promoters
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Xie, Jing et al. (2017) Synthesis, characterization and antitumor activity of Ln(III) complexes with hydrazone Schiff base derived from 2-acetylpyridine and isonicotinohydrazone, Oncol Lett. 2017 Jun;13(6):4413-4419.
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