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Bcl-2 Antibody (Clone Bcl-2/100)

based on 2 citations in multiple journalsBcl-2 Antibody (Clone Bcl-2/100)24.1 4
Catalog #: 3195
$285.00

Product Details

Cat # +Size 3195-100
Size 100 µg
Antibody Target Bcl-2
Alternate Name BCL2, BCL 2
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG1
Immunogen Synthetic peptide corresponding to resides surrounding a.a. 44 of Human Bcl-2
Accession # M13994
Gene ID 596
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 µg (0.5 mg/ml) protein A purified from (low FBS containing) tissue culture supernatant. Purity was >95%. The antibody was formulated in PBS containing 1 mg/ml BSA and 1.5 mM sodium azide and 50% glycerol
Purification Affinity purified
Species Reactivity Human
Application Western blot, Immunoprecipitation, Immunohistochemistry
Application & Usage Western blot (1-4 µg/ml), Immunoprecipitation, Immunohistochemistry, and Flow cytometry. However the optimal conditions should be determined individually. Recognize the 26 kDa human Bcl-2
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Bcl-2 (B-cell leukemia/lymphoma 2) gene was discovered by walking the chromosomal breakpoints t(14;18). This gene consists of two exons and several transcripts that encode two different protein products, Bcl-2α and Bcl-2β. Both proteins are approximately 26-30 kDa and differ at their C-terminal region. Bcl-2 suppresses apoptosis (programmed cell death) and this property appears to be modulated by homodimerization or association with Bax and Bad, two cell death promoters


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Zhu,Taofeng et al. (2017) Design and synthesis of novel N(4)-substituted thiosemicarbazones bearing a pyrrole unit as potential anticancer agents, Oncol Lett. 2017 Jun;13(6):4493-4500
Shen, Shanshan et al. (2017) Synthesis, characterization and anticancer activities of transition metal complexes with a nicotinohydrazone ligand, Oncol Lett. 2017 May;13(5):3169-3176.
Xie, Jing et al. (2017) Synthesis, characterization and antitumor activity of Ln(III) complexes with hydrazone Schiff base derived from 2-acetylpyridine and isonicotinohydrazone, Oncol Lett. 2017 Jun;13(6):4413-4419.
Giuliani, D., et al. (2005) Endocrinology 10.1210/en.2005-0692.
Lu, J., et al. (2004) Am J Physiol Gastrointest Liver Physiol. 286:340-350.
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