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BCI-121

A substrate-competitive SMYD3 inhibitor
Catalog #: B3251
SKU-Size Size Price Qty
B3251-5 5 mg
$145.00
B3251-25 25 mg
$575.00
More Sizes Get Quote

Product Details

Alternate Name BCI121; 4-(Aminocarbonyl)-N-(4-bromophenyl)-1-piperidineacetamide
Peptide Sequence N/A
Appearance White to off-white solid
CAS # 432529-82-3
Molecular Formula C₁₄H₁₈BrN₃O₂
Molecular Weight 340.22
Purity ≥98% by HPLC
Solubility ~20 mg/ml DMSO
SMILES C1CN(CCC1C(=O)N)CC(=O)NC2=CC=C(C=C2)Br
InChi InChI=1S/C14H18BrN3O2/c15-11-1-3-12(4-2-11)17-13(19)9-18-7-5-10(6-8-18)14(16)20/h1-4,10H,5-9H2,(H2,16,20)(H,17,19)
InChi Key KSUYPIXCRPCPGF-UHFFFAOYSA-N
PubChem CID 795875
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BCI-121 is a substrate-competitive SMYD3 inhibitor that reduces nuclear histone H3 lys4 di- and tri-methylation level, downregulates known SMYD3 target genes transcription, and selectively affects SMYD3-dependent proliferation of cancer cultures with little antiproliferation efficacy toward low SMYD3-expressing cancer cells.


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