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A β-Catenin antagonist
Catalog #: B3396
SKU-Size Size Price Qty
B3396-5 5 mg
B3396-25 25 mg
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Product Details

Alternate Name N-[3,6-bis[[(3R,5S)-3,5-dimethylpiperidin-1-yl]sulfonyl]-10-nitrosoanthracen-9-yl]hydroxylamine Tegatrabetan
Appearance Solid
CAS # 1227637-23-1
Molecular Formula C₂₈H₃₆N₄O₆S₂
Molecular Weight 588.74
Purity ≥98%
Solubility >50 mg/ml DMSO
InChi InChI=1S/C28H36N4O6S2/c1-17-9-18(2)14-31(13-17)39(35,36)21-5-7-23-25(11-21)28(30-34)26-12-22(6-8-24(26)27(23)29-33)40(37,38)32-15-19(3)10-20(4)16-32/h5-8,11-12,17-20,29,33H,9-10,13-16H2,1-4H3/t17-,18+,19-,20+
PubChem CID 46212391
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


BC-2059 is a potent inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity. BC-2059 binds to transducin beta-like protein 1 (TBL1) and disrupts the binding of beta-catenin to TBL1. This promotes beta-catenin degradation, attenuates nuclear and cytoplasmic levels of beta-catenin, and reduces transcriptional activity of transcription factor 4 (TCF4) and expression of its target genes, cyclin D1, c-Myc and survivin.

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