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A potent and selective RET and JAK2 inhibitor.
Catalog #: B2114
SKU-Size Size Price Qty
B2114-5 5 mg
B2114-25 25 mg
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Product Details

Alternate Name 5-((6-acetamidopyrimidin-4-yl)oxy)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)indoline-1-carboxamide; NVP-BBT594
Appearance White to off-white solid
CAS # 882405-89-2
Molecular Formula C₂₈H₃₀F₃N₇O₃
Molecular Weight 569.59
Purity ≥98% by HPLC
Solubility DMSO
InChi InChI=1S/C28H30F3N7O3/c1-18(39)34-25-15-26(33-17-32-25)41-22-5-6-24-19(13-22)7-8-38(24)27(40)35-21-4-3-20(23(14-21)28(29,30)31)16-37-11-9-36(2)10-12-37/h3-6,13-15,17H,7-12,16H2,1-2H3,(H,35,40)(H,32,33,34,39)
PubChem CID 59596344
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


BBT-594 is a potent and selective RET and JAK2 inhibitor. It impairs GDNF-RET signaling and GDNF-dependent growth of MCF7-LTED cells. Displays potent anticancer activity.

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