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BB-Cl-Amidine

A pan-peptidylarginine deiminase (PAD) inhibitor
Catalog #: B2847
SKU-Size Size Price Qty
B2847-1 1 mg
$65.00
B2847-5 5 mg
$225.00
More Sizes Get Quote

Product Details

Alternate Name N-[4-[(1-amino-2-chloroethylidene)amino]-1-(1H-benzimidazol-2-yl)butyl]-4-phenylbenzamide; N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-[1,1'-biphenyl]-4-carboxamide
Appearance A crystalline solid
CAS # 1802637-39-3
Molecular Formula C₂₆H₂₆ClN₅O
Molecular Weight 459.97
Purity ≥95%
Solubility ~25 mg/ml in Ethanol
~20 mg/ml in DMSO and DMF
SMILES C1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)NC(CCCN=C(CCl)N)C3=NC4=CC=CC=C4N3
InChi InChI=1S/C26H26ClN5O/c27-17-24(28)29-16-6-11-23(25-30-21-9-4-5-10-22(21)31-25)32-26(33)20-14-12-19(13-15-20)18-7-2-1-3-8-18/ h1-5,7-10,12-15,23H,6,11,16-17H2,(H2,28,29)(H,30,31)(H,32,33)
InChi Key YDOAWJHYHGBQFI-UHFFFAOYSA-N
PubChem CID 134580850
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BB-Cl-Amidine is a pan-peptidylarginine deiminase (PAD) inhibitor. Peptidylarginine deiminase catalyzes the hydrolysis of peptidyl-arginine to form peptidyl-citrulline. BB-Cl-Amidine is a derivative of the PAD inhibitor Cl-amidine in which the C-terminal carboxamide is replaced with a benzimidazole moiety to reduce proteolysis. The cellular potency of BB-Cl-amidine is 20-fold higher than Cl-amidine. The EC₅₀ value for inhibition of viability of U2OS osteosarcoma cells is 8.8 μM. It improves endothelium-dependent vasorelaxation in MRL/lpr mice. It inhibits the formation of neutrophil extracellular traps without altering H₂O₂ production by neutrophils.


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