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A bromodomain inhibitor
Catalog #: B1865

In stock

SKU-Size Size Price Qty
B1865-5 5 mg
B1865-25 25 mg

Product Details

Alternate Name 4-(4-(1-methyl-1H-pyrazol-4-yl)-1-(2-(1-methyl-1H-pyrazol-4-yl)ethyl)-1H-imidazol-5-yl)benzonitrile; BAZ2ICR
Appearance White to of-white solid
CAS # 1665195-94-7 
Molecular Formula C₂₀H₁₉N₇
Molecular Weight 357.41
Purity ≥98% by HPLC
Solubility DMSO (>15 mg/ml)
InChi InChI=1S/C20H19N7/c1-25-12-16(10-23-25)7-8-27-14-22-19(18-11-24-26(2)13-18)20(27)17-5-3-15(9-21)4-6-17/h3-6,10-14H,7-8H2,1-2H3
PubChem CID 91654625
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


BAZ2-ICR is a small molecule inhibitor of BAZ2A (Kd = 109 nM; IC₅₀ = 130 nM) and BAZ2B (Kd = 170 nM; IC50 = 180 nM) bromodomains. It displays 15-fold selectivity for binding BAZ2A/B over CECR2 and >100-fold selectivity over all other bromodomains. BAZ2-ICR has been shown to displace BAZ2 bromodomains in living cells by demonstrating accelerated FRAP recovery at 1 µM in the BAZ2A FRAP assay.

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