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BAY 87-2243

A highly potent and selective inhibitor of hypoxia-induced gene activation.
Catalog #: B1878
SKU-Size Size Price Qty
B1878-5 5 mg
$195.00
B1878-25 25 mg
$775.00
More Sizes Get Quote

Product Details

Alternate Name 5-(1-((2-(4-cyclopropylpiperazin-1-yl)pyridin-4-yl)methyl)-5-methyl-1H-pyrazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole
Appearance Crystalline solid
CAS # 1227158-85-1
Molecular Formula C₂₆H₂₆F₃N₇O₂
Molecular Weight 525.53
Purity ≥98% by HPLC
Solubility DMSO (>7 mg/ml)
SMILES CC1=CC(=NN1CC2=CC(=NC=C2)N3CCN(CC3)C4CC4)C5=NC(=NO5)C6=CC=C(C=C6)OC(F)(F)F
InChi InChI=1S/C26H26F3N7O2/c1-17-14-22(25-31-24(33-38-25)19-2-6-21(7-3-19)37-26(27,28)29)32-36(17)16-18-8-9-30-23(15-18)35-12-10-34(11-13-35)20-4-5-20/h2-3,6-9,14-15,20H,4-5,10-13,16H2,1H3
InChi Key CDJNNOJINJAXPV-UHFFFAOYSA-N
PubChem CID 67377767
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced gene activation. It inhibits HIF-1α and HIF-2α protein accumulation under hypoxic conditions in non-small cell lung cancer (NSCLC) cell line H460 but had no effect on HIF-1α protein levels induced by the hypoxia mimetics desferrioxamine or cobalt chloride. In addition, BAY 87-2243 is also found to act as an inhibitor of mitochondrial function. It can inhibit the oxygen consumption with IC₅₀ value of 10 nM.


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