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BAY 80-6946

A pan-class I PI3K inhibitor
Catalog #: B1267
SKU-Size Size Price Qty
B1267-5 5 mg
$175.00
B1267-25 25 mg
$695.00
More Sizes Get Quote

Product Details

Alternate Name 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide; Copanlisib
Appearance Crystaline solid
CAS # 1032568-63-0
Molecular Formula C₂₃H₂₈N₈O₄
Molecular Weight 480.52
Purity ≥98% by HPLC
Solubility DMSO
SMILES COC1=C(C=CC2=C1N=C(N3C2=NCC3)NC(=O)C4=CN=C(N=C4)N)OCCCN5CCOCC5
InChi nChI=1S/C23H28N8O4/c1-33-19-17(35-10-2-6-30-8-11-34-12-9-30)4-3-16-18(19)28-23(31-7-5-25-20(16)31)29-21(32)15-13-26-22(24)27-14-15/h3-4,13-14H,2,5-12H2,1H3,(H2,24,26,27)(H,28,29,32)
InChi Key PZBCKZWLPGJMAO-UHFFFAOYSA-N
PubChem CID 24989044
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BAY 80-6946 is a highly selective and potent pan-class I PI3K inhibitor with sub-nanomolar IC₅₀s against PI3Kα and PI3Kδ. BAY 80-6946 displays preferential inhibition (about 10-fold) of AKT phosphorylation by PI3Kα compared with PI3Kβ in cells. Shows anticancer properties.


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