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BAY-678

An inhibitor of human neutrophil elastase
Catalog #: B3061
SKU-Size Size Price Qty
B3061-5 5 mg
$175.00
B3061-25 25 mg
$695.00
More Sizes Get Quote

Product Details

Alternate Name 5-[(6R)-5-acetyl-4-methyl-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,6-dihydropyrimidin-6-yl]pyridine-2-carbonitrile; (R)-5-(5-Acetyl-6-methyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydropyrimidin-4-yl)picolinonitrile; 5-[(4R)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile
Appearance Yellow solid
CAS # 675103-36-3
Molecular Formula C₂₀H₁₅F₃N₄O₂
Molecular Weight 400.35
Purity ≥98%
Solubility ~20 mg/ml in DMSO
SMILES CC1=C(C(NC(=O)N1C2=CC=CC(=C2)C(F)(F)F)C3=CN=C(C=C3)C#N)C(=O)C
InChi InChI=1S/C20H15F3N4O2/c1-11-17(12(2)28)18(13-6-7-15(9-24)25-10-13)26-19(29)27(11)16-5-3-4-14(8-16)20(21,22)23/h3-8,10,18H,1-2H3,(H,26,29)/t18-/m1/s1
InChi Key PGIVGIFOWOVINL-GOSISDBHSA-N
PubChem CID 23728722
MDL Number MFCD29924806
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

BAY-678 is a potent, selective, cell-permeable inhibitor of human neutrophil elastase (HNE).The activity of HNE is increased in inflammatory diseases. BAY-678 shows Ki values of 15 nM and 600 nM for human and rat neutrophil elastase respectively and IC₅₀ of 20 nM in vitro. It shows beneficial pulmonary hemodynamic and vascular effects in animal models of pulmonary arterial hypertension. The S-enantiomer BAY-677 is a negative control for BAY-678.


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