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A negative control for BAY-678
Catalog #: B3060
SKU-Size Size Price Qty
B3060-5 5 mg
B3060-25 25 mg
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Product Details

Alternate Name 5-[(6S)-5-acetyl-4-methyl-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,6-dihydropyrimidin-6-yl]pyridine-2-carbonitrile; 5-[(4S)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile
Appearance Yellow solid
CAS # 2117404-84-7
Molecular Formula C₂₀H₁₅F₃N₄O₂
Molecular Weight 400.35
Purity ≥97%
Solubility ~20 mg/ml in DMSO
InChi InChI=1S/C20H15F3N4O2/c1-11-17(12(2)28)18(13-6-7-15(9-24)25-10-13)26-19(29)27(11)16-5-3-4-14(8-16)20(21,22)23/h3-8,10,18H,1-2H3,(H,26,29)/t18-/m0/s1
PubChem CID 68944900
MDL Number MFCD30146413
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


BAY-677 is a negative control for BAY-678. BAY-678 is a potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE) with an IC₅₀ of 20 nM. The S-enantiomer BAY-677 inhibits HNE with IC₅₀>2000 nM.

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