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Bay 61-3606 Hydrochloride

A Syk inhibitor
Catalog #: 1796
SKU-Size Size Price Qty
1796-1 1 mg
$100.00
1796-5 5 mg
$395.00
More Sizes Get Quote

Product Details

Alternate Name 2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide, HCl
Appearance Yellow solid
CAS # 732983-37-8
Molecular Formula C₂₀H₁₈N₆O₃.HCl
Molecular Weight 426.86
Purity ≥98% by HPLC
Solubility H₂O (30 mg/ml) DMSO (2 mg/ml)
SMILES COC1=C(C=C(C=C1)C2=CC3=NC=CN3C(=N2)NC4=C(C=CC=N4)C(=O)N)OC.Cl
InChi InChI=1S/C20H18N6O3.ClH/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19;/h3-11H,1-2H3,(H2,21,27)(H,23,24,25);1H
InChi Key HLYFDKZWVIBYKL-UHFFFAOYSA-N
PubChem CID 52949496
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A potent, ATP-competitive and reversible inhibitor of spleen tyrosine kinase (Syk) (IC₅₀ = 10 nM). Displays excellent selectivity against many other kinases including Btk, Fyn, Itk, Lyn and Src up to concentrations of 4.7 µM. Shows good in vivo efficacy in the treatment of various allergy and asthma conditions in rat models.


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