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BAY 43-9006

based on 2 citations in multiple journalsBAY 43-900624.1 4
A VEGFR and PDGFR kinase inhibitor
Catalog #: 1594

In stock

SKU-Size Size Price Qty
1594-25 25 mg
$120.00
1594-100 100 mg
$350.00
More Sizes Get Quote

Product Details

Appearance Off-white solid
CAS # 475207-59-1
Molecular Formula C₂₁H₁₆ClF₃N₄O₃.C₇H₈O₃S
Molecular Weight 637.03
Purity ≥99%
Solubility DMSO (200 mg/ml)
SMILES CC1=CC=C(C=C1)S(=O)(=O)O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
InChi InChI=1S/C21H16ClF3N4O3.C7H8O3S/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25;1-6-2-4-7(5-3-6)11(8,9)10/h2-11H,1H3,(H,26,30)(H2,28,29,31);2-5H,1H3,(H,8,9,10)
InChi Key IVDHYUQIDRJSTI-UHFFFAOYSA-N
PubChem CID 406563
MDL Number MFCD08235032
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BAY 43-9006 is a novel bi-aryl urea compound that inhibits cell proliferation by targeting the ERK pathway and angiogenesis by targeting the receptor tyrosine kinases VEGFR-2 and PDGFR-β and their associated signaling cascades.


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Lee et al., Arabidopsis Putative MAP Kinase Kinase Kinases Raf10 and Raf11 are Positive Regulators of Seed Dormancy and ABA Response. Plant Cell Physiol., Jan 2015; 56: 84 - 97.
Chen et al., Synergistic Interaction between the HDAC Inhibitor, MPT0E028, and Sorafenib in Liver Cancer Cells In Vitro and In Vivo.Clin. Cancer Res., Mar 2014; 20: 1274 - 1287.
For more citations of this product click here
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