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BAY 43-9006, Free base

A Raf kinase inhibitor
Catalog #: 2142
SKU-Size Size Price Qty
2142-25 25 mg
2142-100 100 mg
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Product Details

Alternate Name Sorafenib
Appearance Off-white solid
CAS # 284461-73-0
Molecular Formula C₂₁H₁₆ClF₃N₄O₃
Molecular Weight 464.82
Purity ≥99% by HPLC
Solubility DMSO (200 mg/ml)
InChi InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
PubChem CID 216239
MDL Number MFCD06411450
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A free base form of BAY 43-9006 (Sorafenib) (Cat. No. 1594-25,100). Acts as an inhibitor of Raf-1 and B-Raf (IC₅₀ = 6 and 22 nM, respectively), as well as several receptor tyrosine kinases, including VEGFR2, VEGFR3, PDGFRβ, FLT3, and c-Kit (IC₅₀ = 90, 15, 20, 57, and 58 nM, respectively. It poorly inhibits ERK1, MEK1, and several other kinases (IC₅₀ = >10 μM).

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Zhimin Wang ., Avicularin ameliorates human hepatocellular carcinoma via the regulation of NF-κB/COX-2/PPAR-γ activities , Mol Med Rep. Apr 19, 31059053
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