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Product Details
| Alternate Name | Sorafenib |
|---|---|
| Appearance | Off-white solid |
| CAS # | 284461-73-0 |
| Molecular Formula | C₂₁H₁₆ClF₃N₄O₃ |
| Molecular Weight | 464.82 |
| Purity | ≥99% by HPLC |
| Solubility | DMSO (200 mg/ml) |
| SMILES | CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F |
| InChi | InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) |
| InChi Key | MLDQJTXFUGDVEO-UHFFFAOYSA-N |
| PubChem CID | 216239 |
| MDL Number | MFCD06411450 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A free base form of BAY 43-9006 (Sorafenib) (Cat. No. 1594-25,100). Acts as an inhibitor of Raf-1 and B-Raf (IC₅₀ = 6 and 22 nM, respectively), as well as several receptor tyrosine kinases, including VEGFR2, VEGFR3, PDGFRβ, FLT3, and c-Kit (IC₅₀ = 90, 15, 20, 57, and 58 nM, respectively. It poorly inhibits ERK1, MEK1, and several other kinases (IC₅₀ = >10 μM).
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Zhimin Wang
., Avicularin ameliorates human hepatocellular carcinoma via the regulation of NF-κB/COX-2/PPAR-γ activities
, Mol Med Rep. Apr 19, 31059053
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