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BAY-1895344 hydrochloride

A potent ATR (ataxia telangiectasia and Rad3-related) protein inhibitor
Catalog #: B1962
SKU-Size Size Price Qty
B1962-5 5 mg
$225.00
B1962-25 25 mg
$895.00
More Sizes Get Quote

Product Details

Alternate Name (R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine hydrochloride
Appearance Yellow solid
CAS # 1876467-74-1 (free base)
Molecular Formula C₂₀H₂₂ClN₇O 
Molecular Weight 411.89
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC1COCCN1C2=NC3=C(C=CN=C3C4=CC=NN4)C(=C2)C5=CC=NN5C
InChi InChI=1S/C20H21N7O/c1-13-12-28-10-9-27(13)18-11-15(17-5-8-23-26(17)2)14-3-6-21-20(19(14)24-18)16-4-7-22-25-16/h3-8,11,13H,9-10,12H2,1-2H3,(H,22,25)/t13-/m1/s1
InChi Key YBXRSCXGRPSTMW-CYBMUJFWSA-N
PubChem CID 118869362
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BAY-1895344, an orally available, potent ATR (ataxia telangiectasia and Rad3-related) protein inhibitor (IC₅₀ = 7 nM). Displays potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride.


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