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A potent, and selective serine/threonine kinase monopolar spindle 1 (Mps1, TTK) inhibitor
Catalog #: B1295
SKU-Size Size Price Qty
B1295-5 5 mg
B1295-25 25 mg
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Product Details

Alternate Name N-Cyclopropyl-4-(6-(2,3-difluoro-4-methoxyphenoxy)-8-((3,3,3-trifluoropropyl)amino)imidazo[1,2-b]pyridazin-3-yl)-2-methylbenzamide
Appearance Crystalline solid
CAS # 1554458-53-5 
Molecular Formula C₂₇H₂₄F₅N₅O₃
Molecular Weight 561.51
Purity ≥98% by HPLC
Solubility DMSO
InChi InChI=1S/C27H24F5N5O3/c1-14-11-15(3-6-17(14)26(38)35-16-4-5-16)19-13-34-25-18(33-10-9-27(30,31)32)12-22(36-37(19)25)40-21-8-7-20(39-2)23(28)24(21)29/h3,6-8,11-13,16,33H,4-5,9-10H2,1-2H3,(H,35,38)
PubChem CID 78320750
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


BAY-1217389 is a potent, and selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1, TTK), with potential antineoplastic activity. Upon administration, BAY-1217389 selectively binds to and inhibits the activity of Mps1. This inactivates the spindle assembly checkpoint (SAC), accelerates mitosis, causes chromosomal misalignment and mitotic checkpoint complex destabilization. 

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