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A potent and highly selective inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1)
Catalog #: B1570
SKU-Size Size Price Qty
B1570-5 5 mg
B1570-25 25 mg
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Product Details

Alternate Name 3-(2-((4-(trifluoromethoxy)phenyl)amino)-1-((1R,5R)-3,3,5-trimethylcyclohexyl)-1H-benzo[d]imidazol-5-yl)propanoic acid
Appearance Crystalline solid
CAS # 1803274-65-8
Molecular Formula C₂₆H₃₀F₃N₃O₃
Molecular Weight 489.5
Purity ≥98% by HPLC
Solubility DMSO
SMILES O=C(O)CCC1=CC=C2N([[email protected]]3CC(C)(C)C[[email protected]@H](C)C3)C(NC4=CC=C(OC(F)(F)F)C=C4)=NC2=C1
InChi InChI=1S/C26H30F3N3O3/c1-16-12-19(15-25(2,3)14-16)32-22-10-4-17(5-11-23(33)34)13-21(22)31-24(32)30-18-6-8-20(9-7-18)35-26(27,28)29/h4,6-10,13,16,19H,5,11-12,14-15H2,1-3H3,(H,30,31)(H,33,34)/t16-,19+/m0/s1
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


BAY-1436032 is a potent and highly selective inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). BAY 1436032 strongly reduces 2-HG (2-hydroxyglutarate) levels in cells carrying IDH1-R132H, -R132C, -R132G, -R132S and -R132L mutations.

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