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Product Details
| Alternate Name | BAY1125976 Imidazo[1,2-b]pyridazine-6-carboxamide, 2-[4-(1-aminocyclobutyl)phenyl]-3-phenyl- |
|---|---|
| Appearance | Crystalline solid |
| CAS # | 1402608-02-9 |
| Molecular Formula | C₂₃H₂₁N₅O |
| Molecular Weight | 383.45 |
| Purity | ≥98% by HPLC |
| Solubility | ~10 mg/ml DMSO |
| SMILES | O=C(C1=NN2C(C=C1)=NC(C3=CC=C(C4(N)CCC4)C=C3)=C2C5=CC=CC=C5)N |
| InChi | InChI=1S/C23H21N5O/c24-22(29)18-11-12-19-26-20(21(28(19)27-18)16-5-2-1-3-6-16)15-7-9-17(10-8-15)23(25)13-4-14-23/h1-3,5-12H,4,13-14,25H2,(H2,24,29) |
| InChi Key | JBGYKRAZYDNCNV-UHFFFAOYSA-N |
| PubChem CID | 70817911 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
BAY-1125976 is a potent and selective allosteric AKT1/2 inhibitor that displays high efficacy on AKT signaling-dependent tumor growth in mouse models. It inhibits Akt1 and Akt2 activity with IC50 values of 5.2 nM and 18 nM at 10 μM ATP, respectively.
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