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BAY 11-7085

An irreversible inhibitor of TNF-α-induced IκBα phosphorylation
Catalog #: B2329

In stock

SKU-Size Size Price Qty
B2329-10 10 mg
$85.00
B2329-50 50 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name (E)-3-(4-t-Butylphenylsulfonyl)-2-propenenitrile,3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-2E-propenenitrile
Appearance White solid
CAS # 196309-76-9
Molecular Formula C₁₃H₁₅NO₂S
Molecular Weight 249.33
Purity ≥98% by HPLC
Solubility >20 mg/ml (EtOH)
>20 mg/ml (DMSO)
SMILES CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)C=CC#N
InChi InChI=1S/C13H15NO2S/c1-13(2,3)11-5-7-12(8-6-11)17(15,16)10-4-9-14/h4-8,10H,1-3H3/b10-4+
InChi Key VHKZGNPOHPFPER-ONNFQVAWSA-N
PubChem CID 5353432
MDL Number MFCD01862602
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

BAY 11-7085 is an irreversible inhibitor of IκBα phosphorylation, preventing activation of NF-κB by cytokines and lipopolysaccharide (IC50 = 10 μM). It prevents gene expression that is regulated through the classical pathway of NF-κB activation and thus blocks apoptosis, cell adhesion, and inflammation.


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