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BAY 11-7082

A NF-κB activation inhibitor
Catalog #: 1867
SKU-Size Size Price Qty
1867-10 10 mg
$120.00
1867-50 50 mg
$475.00
More Sizes Get Quote

Product Details

Alternate Name (E)-3-(4-Methylphenylsulfonyl)-2-propenenenitrile
Appearance White to off-white solid
CAS # 19542-67-7
Molecular Formula C₁₀H₉NO₂S
Molecular Weight 207.25
Purity ≥98%
Solubility DMSO or EtOH
SMILES CC1=CC=C(C=C1)S(=O)(=O)C=CC#N
InChi InChI=1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+
InChi Key DOEWDSDBFRHVAP-KRXBUXKQSA-N
PubChem CID 5353431
MDL Number MFCD00712162
Handling Protect from air and light
Storage Conditions 4°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Potential anti-inflammatory agent. Selectively and irreversibly inhibits NF-κB activation by blocking TNF-α-induced phosphorylation of IκB-α without affecting constitutive IκB-α phosphorylation. Inhibits the TNF-α-induced surface expression of adhesion molecules ICAM-1, VCAM-1, and E-selectin in human endothelial cells with IC₅₀ values of 5-10 µM.


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