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BAX Activator, BAM7

A potent and selective BAX activator
Catalog #: 2451
SKU-Size Size Price Qty
2451-5 5 mg
$95.00
2451-25 25 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name 3-Methyl-1-(4-phenyl-2-thiazolyl)-1​H-pyrazole-4,5-dione 4-[2-(2-Ethoxyphenyl)hydrazone]; BAM7
Appearance Brown solid
CAS # 331244-89-4
Molecular Formula C₂₁H₁₉N₅O₂S
Molecular Weight 405.47
Purity ≥98% by HPLC
Solubility DMSO (~ 2 mg/ml)
SMILES CCOC1=CC=CC=C1NN=C2C(=NN(C2=O)C3=NC(=CS3)C4=CC=CC=C4)C
InChi InChI=1S/C21H19N5O2S/c1-3-28-18-12-8-7-11-16(18)23-24-19-14(2)25-26(20(19)27)21-22-17(13-29-21)15-9-5-4-6-10-15/h4-13,23H,3H2,1-2H3/b24-19+
InChi Key KOCVKGYKBLJEPK-LYBHJNIJSA-N
PubChem CID 5754137
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent and selective BAX activator (EC₅₀ = 3.3 μM). BAM7 directly binds at the BH3-binding site; selective for BAX over other antiapoptotic and proapoptotic proteins. BAM7 triggers in vitro BAX oligomerization, BAX-mediated pore formation and BAX-dependent cell death. BAM7 selectively induces BAX-mediated apoptosis by triggering the hallmark features of intracellular BAX activation. BAM7 only kills the cell line that contains BAX, eliciting the biochemical and morphologic features of BAX-mediated apoptosis.


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