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Product Details
| Alternate Name | 2-[1-Ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile; INCB 028050;LY 3009104;INCB028050;LY3009104;LY-3009104;INCB-028050 |
|---|---|
| Appearance | White to off-white solid |
| CAS # | 1187594-09-7 |
| Molecular Formula | C₁₆H₁₇N₇O₂S |
| Molecular Weight | 371.42 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (>50 mg/ml) |
| SMILES | CCS(=O)(=O)N1CC(C1)(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3 |
| InChi | InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20) |
| InChi Key | XUZMWHLSFXCVMG-UHFFFAOYSA-N |
| PubChem CID | 44205240 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Baricitinib is a selective JAK1 and JAK2 inhibitor with IC₅₀ values of 5.9 nM and 5.7 nM, respectively. Baricitinib is ~70 and ~10-fold selective versus JAK3 and Tyk2, with no inhibition to c-Met and Chk2.
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