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Baricitinib phosphate

A potent and selective JAK1 and JAK2 inhibitor
Catalog #: 2841
SKU-Size Size Price Qty
2841-10 10 mg
$115.00
2841-50 50 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name 2-[1-Ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile, phosphoric acid; NCB 028050;LY 3009104;INCB028050;LY3009104;LY-3009104;INCB-028050
Appearance Pale yellow to yellow solid
CAS # 1187595-84-1
Molecular Formula C₁₆H₂₀N₇O₆PS
Molecular Weight 469.41
Purity ≥98% by HPLC
Solubility DMSO (~ 1 mg/ml)
SMILES CCS(=O)(=O)N1CC(C1)(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3.OP(=O)(O)O
InChi InChI=1S/C16H17N7O2S.H3O4P/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14;1-5(2,3)4/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20);(H3,1,2,3,4)
InChi Key FBPOWTFFUBBKBB-UHFFFAOYSA-N
PubChem CID 44231848
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Baricitinib phosphate is a selective JAK1 and JAK2 inhibitor with IC₅₀ values of 5.9 nM and 5.7 nM, respectively. Baricitinib is ~70 and ~10-fold selective versus JAK3 and Tyk2, with no inhibition to c-Met and Chk2.


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