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Bardoxolone

An iNOS inhibitor
Catalog #: B1170
SKU-Size Size Price Qty
B1170-5 5 mg
$125.00
B1170-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name 2-cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid; RTA 402; CDDO
Appearance Light brown Solid
CAS # 218600-44-3
Molecular Formula C₃₁H₄₁NO₄
Molecular Weight 491.66
Purity ≥98% by HPLC
Solubility DMSO (>4.5 mg/ml)
SMILES CC1(CCC2(CCC3(C(C2C1)C(=O)C=C4C3(CCC5C4(C=C(C(=O)C5(C)C)C#N)C)C)C)C(=O)O)C
InChi 1S/C31H41NO4/c1-26(2)10-12-31(25(35)36)13-11-30(7)23(19(31)16-26)20(33)14-22-28(5)15-18(17-32)24(34)27(3,4)21(28)8-9-29(22,30)6/h14-15,19,21,23H,8-13,16H2,1-7H3,(H,35,36)/t19-,21-,23-,28-,29+,30+,31-/m0/s1
InChi Key TXGZJQLMVSIZEI-UQMAOPSPSA-N
PubChem CID 400010
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Bardoxolone is a synthetic oleanane triterpenoid that inhibits cellular iNOS production when stimulated by IFNg, TNF-α and IL-1. It is Reata’s investigational lead molecule for CKD (chronic kidney disease). It is a potent inducer of the transcription factor Nrf2 which is an important biological target that controls the production of many of the body’s antioxidant and detoxification enzymes.


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